FIELD: biotechnology.
SUBSTANCE: group of inventions relates to peptide nucleic acid derivatives targeting 3'-splice site of pre-mRNA human SNAP25, and their use for treating a dermatological indication or a condition mediated by high human SNAP25 gene expression. Peptide nucleic acid derivatives actively induce at least a variant of human SNAP25 mRNA splicing in cells and can be used for the safe treatment of dermatological indications or conditions involving human SNAP25 protein expression by local administration.
EFFECT: antisense oligonucleotides for SNAP25 are disclosed.
10 cl, 19 dwg, 2 tbl, 7 ex
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