FIELD: biotechnology.
SUBSTANCE: following is described: a group of inventions, including a peptide nucleic acid derivative for inducing exon skipping in human ACC-2 pre-mRNA and a method of inducing exon 12 skipping in human ACC-2 pre-mRNA to obtain a splicing variant of ACC-2 mRNA without exon 12 of ACC-2 in cells in vitro. The peptide nucleic acid derivative has at least a 10-mer complementary overlap with the 18-mer pre-mRNA sequence [(5'→3')GGCCAUUUCGUCAGUAUC] in the human ACC-2 pre-mRNA.
EFFECT: invention expands the arsenal of agents for inducing exon skipping in human ACC-2 pre-mRNA.
5 cl, 11 dwg, 4 tbl, 6 ex
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