ANTISENSE OLIGONUCLEOTIDES OF MATRIX METALLOPROTEINASE-1 Russian patent published in 2023 - IPC C12N15/113 C07K14/00 A61K31/7088 A61K8/60 A61K8/64 A61P17/00 A61Q19/08 

FIELD: pharmaceuticals.

SUBSTANCE: group of inventions relates to derivatives of peptide nucleic acids (PNA) targeting human matrix metalloproteinase-1 (MMP-1) pre-mRNA and their use for the treatment of skin aging conditions associated with human MMP-1 protein. A PNA derivative of formula I or a pharmaceutically acceptable salt thereof for inducing exon skipping in human MMP-1 pre-mRNA are proposed. A PNA derivative has at least a 14-dimensional complementary overlap with a 16-dimensional pre-mRNA sequence [(5'→ 3') CAUAUAUGGUGAGUAU] in human MMP-1 pre-mRNA. Also a pharmaceutical composition and a cosmetic composition for reducing skin aging associated with human MMP-1, and a method of reducing skin aging are proposed.

EFFECT: PNA derivative has good cellular or membrane permeability, can be locally administered as a "naked" oligonucleotide to induce MMP-1 "exon 5" skipping in the skin, improve skin condition and prevent its aging.

6 cl, 13 dwg, 8 ex