FIELD: biotechnology.
SUBSTANCE: group of inventions relates to the field of biotechnology, in particular to derivatives of peptide nucleic acid targeted to 3'-section of exon 4 splicing in pre-mRNA of human SCN9A; it can be used in medicine. Derivatives of peptide nucleic acid actively induce options of splicing of SCN9A mRNA depleted in SCN9A exon 4 in mammalian cells, due to which they can be used for the safe treatment of different kinds of diseases or conditions involving activity of sodium-ion channels of NaV1.7-type.
EFFECT: obtaining derivatives of peptide nucleic acid for the safe treatment of diseases.
16 cl, 24 dwg, 2 tbl, 22 ex
| Title | Year | Author | Number |
|---|---|---|---|
| EXON SKIP WITH PEPTIDONUCLEIC ACID DERIVATIVES | 2017 |
|
RU2786637C2 |
| ANTISENSE OLIGONUCLEOTIDES AGAINST SCN9A | 2017 |
|
RU2748834C2 |
| ANTISENSE OLIGONUCLEOTIDES FOR SNAP25 | 2017 |
|
RU2766701C2 |
| ANTISENSE OLIGONUCLEOTIDES TO HIF-1-ALPHA | 2017 |
|
RU2753517C2 |
| ANTISENSE OLIGONUCLEOTIDES OF ANDROGEN RECEPTOR | 2017 |
|
RU2753966C2 |
| ANTISENSE TYROSINASE OLIGONUCLEOTIDES | 2018 |
|
RU2778786C2 |
| ANTISENSE OLIGONUCLEOTIDES OF ACETYL-COA-CARBOXYLASE-2 | 2019 |
|
RU2807629C2 |
| ANTISENSE OLIGONUCLEOTIDES OF MATRIX METALLOPROTEINASE-1 | 2019 |
|
RU2802418C2 |
| PEPTIDE NUCLEIC ACID DERIVATIVES WITH GOOD CELL PENETRATION AND STRONG AFFINITY FOR NUCLEIC ACID | 2009 |
|
RU2564032C2 |
| NOVEL MONOMERS AND OLIGOMERS OF PEPTIDE NUCLEIC ACIDS | 2015 |
|
RU2693827C2 |
