FIELD: biotechnology.
SUBSTANCE: present invention relates to the field of biotechnology, in particular to poly-specific antibodies; it can be used in medicine. The invention discloses new proteins, which specifically bind to NKG2D receptor, CD16, and CEA tumor-specific agent.
EFFECT: invention can be used in medical practice as a therapeutic agent in the treatment of a row of malignant neoplasms, for example gastrointestinal cancer, colorectal cancer, pancreatic cancer, non-small cell lung cancer, and breast cancer.
24 cl, 37 dwg, 14 tbl, 10 ex
| Title | Year | Author | Number |
|---|---|---|---|
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|
RU2788531C2 |
| PROTEIN BINDING WITH NKG2D, CD16 AND WITH TUMOR-SPECIFIC ANTIGEN | 2018 |
|
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| PROTEINS BINDING NKG2D, CD16 AND TUMOUR-ASSOCIATED ANTIGEN | 2018 |
|
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|
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| MODIFIED NON-NATURAL NKG2D LIGANDS WHICH SELECTIVELY DELIVER ATTACHED HETEROLOGOUS MOLECULES TO NON-NATURAL NKG2D RECEPTORS ON CAR CELLS | 2020 |
|
RU2823728C2 |
| MODIFIED Α1-Α2 DOMAINS OF NON-NATURAL NKG2D LIGANDS THAT BIND TO NON-NATURAL NKG2D RECEPTORS | 2019 |
|
RU2815278C2 |
| POLYVALENT BINDING PROTEINS FOR ACTIVATION OF NATURAL KILLER CELLS AND THEIR THERAPEUTIC APPLICATION FOR TREATMENT OF MALIGNANT NEOPLASM | 2018 |
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RU2809125C2 |
| CRYOPRESERVED CELLS ARE NATURAL KILLERS PRELOADED WITH ANTIBODY CONSTRUCTION | 2019 |
|
RU2819927C2 |
