CRYSTALLINE FORM OF MALEATE OF CONDENSED PYRIDINE DERIVATIVE AND METHODS FOR USE THEREOF Russian patent published in 2020 - IPC C07D487/04 C07D401/14 A61K31/437 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a crystalline form of a maleate salt of N-(4-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide of formula (I), where its X-ray powder pattern is characterized by characteristic peaks at diffraction angles 2θ at values of 8.6° ± 0.2°, 15.8° ± 0.2°, 16.5° ± 0.2°, 19.5° ± 0.2°, 20.2° ± 0.2° and 26.5° ± 0.2°; wherein powder X-ray diffraction pattern is obtained using X-ray diffraction system D8-Advance and K-alpha radiation of copper anode of X-ray tube as radiation source. Method of producing a crystalline form of formula I involves reacting a compound of formula II with maleic acid in a reaction medium based on ethyl acetate in a glass reactor at room temperature, centrifuging and drying overnight under vacuum at room temperature to obtain the desired crystalline form.

EFFECT: crystalline maleate salt of N-(4-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide is intended for preparing a drug preparation or pharmaceutical composition for treating a c-Met-mediated disorder.

14 cl, 3 tbl, 3 dwg, 13 ex