FIELD: immunology.
SUBSTANCE: antibody to human CD73 or its antigen-binding fragment, a fused protein, polynucleotides, expression vectors, and a host cell are proposed. Besides, methods for producing an antibody to human CD73 or its antigen-binding fragment, a method for producing a fused protein, pharmaceutical compositions, as well as methods for preventing or treating cancer, using an antibody to human CD73, using a fused protein are considered.
EFFECT: present invention can be further used in the therapy of cancer expressing CD73.
35 cl, 3 dwg, 4 tbl, 7 ex
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