FIELD: biotechnology.
SUBSTANCE: invention relates to production of glycosylated polypeptides having affinity for somatostatin receptors and can be used in medicine for somatostatin-related diseases treatment or prevention. SRIF14 and SRIF28 glycosylated polypeptides are obtained by Asn or Cys glycosylation.
EFFECT: invention provides preparation of glycosylated polypeptides having an affinity for somatostatin receptors and better stability in blood compared to somatostatin.
14 cl, 19 dwg, 10 tbl, 88 ex
Title | Year | Author | Number |
---|---|---|---|
GLYCOSYLATED POLYPEPTIDES AND MEDICINAL COMPOSITIONS CONTAINING THESE POLYPEPTIDES | 2012 |
|
RU2627184C2 |
SACCHARIDE CHAIN-POLYPEPTIDE COMPLEXES | 2014 |
|
RU2664539C2 |
POLYPEPTIDE GLYCOSYLATED WITH SIALYLATED SUGAR CHAIN | 2014 |
|
RU2668163C2 |
GLP-1 PEPTIDE HAVING ATTACHED OLIGOSACCHARIDE CHAIN | 2008 |
|
RU2539829C2 |
GLYCOSYLATED POLYPEPTIDE AND ITS PHARMACEUTICAL COMPOSITION | 2012 |
|
RU2636456C2 |
PROCESS FOR PREPARATION OF GLYCOPEPTIDE HAVING SIALYLATED SUGAR CHAIN, AND METHOD FOR PRODUCING SIALYL GLYCOASPARAGINE | 2012 |
|
RU2586524C2 |
GLYCATED PEPTIDE GLP-1 | 2009 |
|
RU2543157C2 |
HIGHLY EFFICIENT METHOD OF PRODUCING POLYPEPTIDE FRAGMENT SUITABLE FOR NCL | 2012 |
|
RU2605411C2 |
METHOD OF PRODUCING GLYCOPROTEIN AND SCREENING METHOD | 2009 |
|
RU2520240C2 |
POLYPEPTIDE DERIVATIVES, METHOD OF CALCIUM CHANNEL INHIBITION | 1993 |
|
RU2120945C1 |
Authors
Dates
2017-06-30—Published
2012-09-03—Filed