METHOD FOR CLEAVAGE OF SOLID PHASE-BOUND PEPTIDES FROM THE SOLID PHASE Russian patent published in 2022 - IPC C07K1/04 C07K14/605 C07K14/575 

FIELD: chemistry.

SUBSTANCE: invention relates to a method for cleavage of a solid phase-bound polypeptide from the solid phase, wherein the method involves bringing the solid phase whereto the polypeptide is bound into contact with a composition consisting substantially of trifluoroacetic acid and 1,2-ethanediol at a temperature from 23 to 29°C, wherein the composition is brought into contact with the solid phase whereto the polypeptide is bound for a period of 3 to 5 hours, wherein the polypeptide is selected from GLP-1, analogues and derivatives thereof, exendin-3, analogues and derivatives thereof, and exendin-4, analogues and derivatives thereof.

EFFECT: method allows for an increase in the yield of the peptide.

10 cl, 20 dwg, 30 tbl, 7 ex