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(19)

(11)

2 786 659

(13)

(51)

IPC

A61K39/395(2006-01-01)

C07K16/44(2006-01-01)

C07K16/18(2006-01-01)

C07K16/40(2006-01-01)

A61P19/02(2006-01-01)

(21) (22)

Application

2019143684, 2018-06-04

(24)

Start date

2018-06-04

(22)

Actual filing date

2018-06-04

(45)

Published

2022-12-23

(72)

Inventor

Steffensen, SorenBeste, GeraldGuehring, HansToleikis, LarsLadel, ChristophLindemann, SvenKellner, RolandGuenther, Ralf

(73)

Holder

Merck Patent GmbhAblynx Nv

POLYPEPTIDES BINDING TO ADAMTS5, MMP13, AND AGGRECAN Russian patent published in 2022 - IPC A61K39/395 C07K16/44 C07K16/18 C07K16/40 A61P19/02

Abstract RU 2786659 C2

FIELD: biotechnology.

SUBSTANCE: present invention relates to the field of biotechnology, in particular to new hybrid immunoglobulins; it can be used in medicine. The invention discloses polypeptides capable of binding to proteoglycan cartilage aggrecan protein. ADAMTS5, and/or MMP13, as well as structures based on them.

EFFECT: invention can be used in medical practice in the treatment or prevention of joint diseases for prevention of cartilage tissue erosion, in particular in osteoarthritis.

21 cl, 11 dwg, 25 tbl, 14 ex

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RU 2 786 659 C2

Authors

Steffensen, Soren

Beste, Gerald

Guehring, Hans

Toleikis, Lars

Ladel, Christoph

Lindemann, Sven

Kellner, Roland

Guenther, Ralf

Dates

2022-12-23—Published

2018-06-04—Filed