BIOLOGICAL MARKERS USABLE IN IMMUNOTHERAPY FOR CANCER Russian patent published in 2021 - IPC A61K38/10 A61P35/00 

Abstract RU 2756548 C1

FIELD: medicine.

SUBSTANCE: invention relates to an application of a composition comprising a polypeptide consisting of SEQ ID NO: 1 (EARPALLTSRLRFIPK (GV1001)) for producing a medicinal product for preventing suppression of the immune function caused by treatment of pancreatic cancer, wherein the composition is administered simultaneously with a chemotherapeutic agent, wherein the chemotherapeutic agent constitutes gemcitabine, capecitabine, or a combination thereof, and the composition does not reduce the level of one or more cytokines selected from the group consisting of IL1β, IL-1ra, IL-2, IL-4, IL-5, IL-7, IL-10, IL-12, IL-13, IL-17, GCSF, IFNγ, eotaxin, MIP1β, RANTES and TNFα, in the serum. Also proposed is an application of the set for preventing suppression of the immune function caused by anticancer treatment of pancreatic cancer, including a polypeptide defined in claim 1 and a chemotherapeutic agent, wherein the chemotherapeutic agent constitutes gemcitabine, capecitabine, or a combination thereof.

EFFECT: application of a polypeptide composition for preventing suppression of the immune function caused by treatment of pancreatic cancer.

6 cl, 25 dwg, 6 tbl, 1 ex

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RU 2 756 548 C1

Authors

Kim, Sang Jae

Dates

2021-10-01Published

2020-06-26Filed