METHOD FOR OBTAINING REMDESIVIR AND PHOSPHORAMIDATES Russian patent published in 2021 - IPC C07F9/24 C07H19/10

Abstract RU 2756921 C1

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a method for producing remdesivir, including interaction in the presence of a nucleoside base of formula (II)

where R1 and R2 together or separately represent H or a protective group, with the phosphoramidate of formula (III)

where X represents and also the removal of the protective group, if R1 and R2 together are not H. Also, the invention relates to phosphoramidates of formula III.

EFFECT: present invention makes it possible to obtain remdesivir with high yield, chemical and optical purity, using the simplicity of the technology.

6 cl, 9 ex

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RU 2 756 921 C1

Authors

Popova Tatyana Evgenevna

Ryzhkov Igor Olegovich

Dates

2021-10-07—Published

2020-11-20—Filed