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(19)

(11)

2 740 058

(13)

(51)

IPC

A61K31/7072(2006-01-01)

C07F9/24(2006-01-01)

C07H19/10(2006-01-01)

(21) (22)

Application

2020121360, 2020-06-26

(24)

Start date

2020-06-26

(22)

Actual filing date

2020-06-26

(45)

Published

2020-12-31

(72)

Inventor

Burdejnyj Maksim LvovichDashkin Ratmir RinatovichKochetkov Sergej ViktorovichFlegontov Pavel AlekseevichShishanov Mikhail Valentinovich

(73)

Holder

Obshchestvo S Ogranichennoj Otvetstvennostyu Lekarstv"

METHOD OF PRODUCING SOFOSBUVIR AND PHOSPHORAMIDATES Russian patent published in 2020 - IPC A61K31/7072 C07F9/24 C07H19/10

Abstract RU 2740058 C1

FIELD: pharmaceutics.

SUBSTANCE: invention can be used in pharmaceutical industry and relates to a method for preparing an antiviral compound of sofosbuvir of formula (I):

formula (I),

as well as intermediate compounds for its implementation. Disclosed method comprises reacting in the presence of a nucleoside base of formula (II) with a phosphoramidate of formula (III)

where X is

EFFECT: disclosed are new phosphoramidates and a new efficient method of producing sofosbuvir with use thereof.

5 cl, 9 ex

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RU 2 740 058 C1

Authors

Burdejnyj Maksim Lvovich

Dashkin Ratmir Rinatovich

Kochetkov Sergej Viktorovich

Flegontov Pavel Alekseevich

Shishanov Mikhail Valentinovich

Dates

2020-12-31—Published

2020-06-26—Filed