FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, in particular to an antibody or its antigen-binding fragment that specifically binds to MELK (maternal embryonic leucine zipper kinase) protein or its partial peptide, a method for its production, as well as to a reagent containing it and a labeled body. Polynucleotide encoding the above-mentioned antibody or its fragment is also disclosed.
EFFECT: invention is effective for the detection of MELK protein in a sample, for the determination of the drug effect after the treatment using MELK inhibitor in a subject, as well as for the diagnostics of MELK-associated disease or predisposition to the development of the specified disease in a subject.
15 cl, 4 dwg, 4 ex
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