FIELD: biotechnology.
SUBSTANCE: present invention relates to novel multispecific binding antibodies, and can be used in medicine. Invention discloses a protein, the molecule of which contains domains which specifically bind to the receptor with the NKG2D receptor, with CD16 and with the tumour-associated antigen nectin-4.
EFFECT: invention can be used in immunotherapy of malignant tumours, cells of which express nectin-4 on their surface.
28 cl, 8 ex, 11 tbl, 43 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| PROTEIN BINDING WITH NKG2D, CD16 AND WITH TUMOR-SPECIFIC ANTIGEN | 2018 |
|
RU2788531C2 |
| POLYSPECIFIC BINDING PROTEINS TARGETING NKG2D, CD16 AND TROP2 | 2018 |
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|
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| MODIFIED Α1-Α2 DOMAINS OF NON-NATURAL NKG2D LIGANDS THAT BIND TO NON-NATURAL NKG2D RECEPTORS | 2019 |
|
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| BCMA, NKG2D AND CD16 BINDING PROTEINS | 2018 |
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| CD33, NKG2D AND CD16 BINDING PROTEINS | 2018 |
|
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| POLYVALENT BINDING PROTEINS FOR ACTIVATION OF NATURAL KILLER CELLS AND THEIR THERAPEUTIC APPLICATION FOR TREATMENT OF MALIGNANT NEOPLASM | 2018 |
|
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| ADAM9-BINDING MOLECULES AND THEIR APPLICATION METHODS | 2017 |
|
RU2783619C2 |
| CRYOPRESERVED CELLS ARE NATURAL KILLERS PRELOADED WITH ANTIBODY CONSTRUCTION | 2019 |
|
RU2819927C2 |
| CD47-ANTIGEN-BINDING UNIT AND ITS USE | 2018 |
|
RU2780859C2 |
