FIELD: biotechnology.
SUBSTANCE: present invention relates to the field of biotechnology, specifically to a conjugate of an antibody specific to CAPRIN-1 protein or its antigen-binding fragment with an immune activator. The invention allows for obtaining a new conjugate of an anti-CAPRIN-1 antibody with immune activators, in particular with TL7/8 agonists – reziquimod or its derivatives, that has significantly stronger antitumor effect compared to immunoconjugates known from the technology level.
EFFECT: invention can be used in medicinal practice as a drug in the treatment of malignant neoplasms expressing CAPRIN-1 protein on the surface of cell membrane.
12 cl, 11 ex
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