METHOD FOR PREDICTING ADVERSE PREGNANCY OUTCOMES IN WOMEN WITH TYPE 1 DIABETES MELLITUS IN THE SECOND HALF OF PREGNANCY Russian patent published in 2021 - IPC G01N33/48 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely obstetrics and endocrinology, and can be used to predict adverse pregnancy outcomes in women with type 1 diabetes mellitus (DM) in the second half of pregnancy. The risk factors for development of adverse pregnancy outcomes are estimated: the duration of DM of more than 10 years, the age of onset of DM less than 13 years, the presence of microalbuminuria and/ or proteinuria, the presence of chronic kidney disease, the presence of preproliferative or proliferative retinopathy. At the terms of 22 to 24 and 30 to 32 weeks of pregnancy, doses of insulin are determined and the growth rate of the basal dose of insulin is calculated by the formula [(x_n-x _n-1)/x_n-1]*100%, wherein x_n is the dose of insulin at 30 to 32 weeks in units/kg of body weight, x_n-1 is the dose of insulin at 22 to 24 weeks in units/kg of body weight. If risk factors for development of adverse pregnancy outcomes are present and the growth rate of basal doses of insulin is less than 4.5%, an adverse outcome is predicted with development of prematurity and fetal respiratory distress syndrome. If risk factors for development of adverse pregnancy outcomes are present and the growth rate is more than or equal to 4.5% and less than 19.5%, an adverse outcome is predicted with development of fetoplacental insufficiency, preeclampsia, early delivery, intrauterine fetal development retardation.

EFFECT: method provides a possibility of predicting the pregnancy outcomes in women with type 1 diabetes mellitus for practical use and identifying a high risk group for adverse obstetric complications and pregnancy outcomes due to the estimation of risk factors for development of adverse pregnancy outcomes and calculation of the growth rate of the basal dose of insulin at the terms of 22 to 24 and 30 to 32 weeks of pregnancy.

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