FIELD: medicine; oncology.
SUBSTANCE: present invention relates to the field of medicine, namely to oncology; it is intended for the treatment of BRAF-associated cancer, while it includes injection to a patient who needs it of a combination therapy that independently includes therapeutically effective amounts of: (a) BRAF inhibitor, which is methyl-N-[(2S)-1-({4-[3-(5-chloro-2fluoro-3-methanesulfonamidophenyl)-1-(propane-2-yl)-1H-pyrazole-4-yl]pyrimidine-2-yl}amino)propane-2-yl]carbamate (COMPOUND A), (b) MEK inhibitor (COMPOUND B), which is (2-hydroxyethoxy)amide of 6-(4-bromine-2-fluorphenylamino)-7-fluoro-3-methyl-3H-benzimidazole-5-carboxylic acid, and (c) an antibody against EGFR (COMPOUND C), which is cetuximab.
EFFECT: effective and long-term treatment of cancer using a combination therapy method.
30 cl, 14 tbl, 8 dwg, 4 ex
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