4-OXO-3,4-DIHYDROQUINAZOLINONE COMPOUNDS FOR TREATMENT OF BRAF-ASSOCIATED DISEASES AND DISORDERS Russian patent published in 2024 - IPC C07D239/90 C07D401/12 C07D403/12 C07D405/12 A61P35/00 A61K31/517 

Abstract RU 2814662 C1

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a compound of N-(2-chloro-3-((5-chloro-3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)-4-fluorophenyl)-3- fluoroazetidine-1-sulfonamide of formula I, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition based on it, as well as a method of treating a BRAF-associated tumour using them.

EFFECT: obtaining of 4-oxo-3,4-dihydroquinazolinone compounds for the treatment of BRAF-associated diseases and disorders.

25 cl, 1 dwg, 140 ex

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RU 2 814 662 C1

Authors

Bettendorf, Tanna Marie

Doerner Barbour, Patrick Michael

Kahn, Dean Russell

Kellum, Alex Andrew

Laird, Ellen Ruth

Moreno, David Austin

Ren, Li

Dates

2024-03-04Published

2021-06-04Filed