FIELD: organic chemistry.
SUBSTANCE: invention relates to the compound of formula III or its pharmaceutically acceptable salt, where L is NH or O; X1 is CH or N; R1 is either C1-C6 alkyl or C1-C6 deuteroalkyl; R2 is methyl; R3 is either F or Cl; R4 is either H or F; R5 is either H or F; and R6 is either C1-C6 alkyl or C1-C6 fluoroalkyl. The invention also relates to anhydrous forms A and B of N-(2-chloro-3-((3,5-dimethyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)-4-fluorophenyl)-3- fluoropropane-1-sulfonamide and a pharmaceutical composition based on these compounds.
EFFECT: effective treatment of a BRAF-associated tumor.
6 cl, 17 dwg, 31 tbl, 90 ex
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