METHOD FOR DIAGNOSING ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS IN PATIENTS WITH BRONCHIAL ASTHMA Russian patent published in 2021 - IPC G01N33/569 G01N33/68 G01N33/49 A61B6/03 

FIELD: medicine; allergology; immunology; mycology; pulmonology.

SUBSTANCE: invention relates to medicine, namely to allergology, immunology, mycology, pulmonology; it can be used to diagnose allergic bronchopulmonary aspergillosis (hereinafter – ABPA) in patients with bronchial asthma. Clinical and laboratory studies are carried out, including skin testing with Aspergillus fumigatus and/or determination of specific IgE to Aspergillus fumigatus, as well as total IgE, IgG to Aspergillus fumigatus, the absolute number of eosinophils in peripheral blood, as well as X-ray examination of the lungs, including assessment of infiltrative and focal changes and visualization of bronchiectasis. At a positive result of skin testing with Aspergillus fumigatus and/or a value of specific IgE to Aspergillus fumigatus > 0.35 IU/ml, as well as total IgE > 1000 IU/ml and with at least two of three criteria listed below: at the absolute number of eosinophils in peripheral blood > 500 cl/mcl in patients not receiving systemic steroids, at IgG to Aspergillus fumigatus value higher than normal, at the presence of eosinophil infiltrates, bronchiectasis and pleuropulmonary fibrosis at X-ray examination of the lungs, ABPA is diagnosed in patients with bronchial asthma. At the total IgE value of < 1000 IU/ml, thymus-associated regulatory chemokine and periostin are additionally determined in the blood serum. At the value of thymus-associated regulatory chemokine > 511 pg/ml and periostin > 29 ng/ml, ABPA is diagnosed in patients with bronchial asthma.

EFFECT: method makes it possible to increase the accuracy, specificity, sensitivity of the diagnostics of ABPA in patients with bronchial asthma by establishing the diagnosis of ABPA based on a combination of clinical, radiological and immunological signs, including the totality of values of thymus-associated regulatory chemokine and periostin, which is an additional new criterion for the diagnosis of ABPA at the total IgE value < 1000 IU/ml.

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