NEW COMPOUND FOR DIRECT INHIBITION OF ASM ACTIVITY, WHICH IS DERIVATIVE OF 2-AMINO-2-(1,2,3-TRIAZOL-4-YL)PROPANE-1,3-DIOL, AND ITS APPLICATION Russian patent published in 2021 - IPC C07D249/04 A61K31/4192 A61P25/00 A61P25/24 

FIELD: pharmacology; medicine.

SUBSTANCE: group of inventions relates to the field of pharmacology and medicine, namely, a new compound is described, represented by chemical formula 1 or its pharmacologically acceptable salt: where R₁ is hydrogen, and R₂ is an alkyl of 6-9 carbon atoms. In addition, the use of a compound of chemical formula 1 for the preparation of a means for the prevention or treatment of a neurodegenerative disease or depression, pharmaceutical and food compositions based on a compound of formula 1 for the prevention or treatment of a neurodegenerative disease or depression are described. Also described is a method for the prevention or treatment of a neurodegenerative disease or depression, including the introduction of an effective amount of a composition containing a compound of chemical formula 1, and a method for the diagnosis of a neurodegenerative disease or depression, including the introduction of an effective amount of a composition containing a compound of chemical formula 1 or its pharmacologically acceptable salt, with which a diagnostic agent or detection agent is associated, as an active ingredient, to an individual with suspected neurodegenerative diseases or depression.

EFFECT: new compound with the effect of direct inhibition of ASM activity was obtained and described, demonstrating an excellent effect in the treatment of neurodegenerative diseases and depression.

Formula 1

11 cl, 21 dwg, 1 tbl