AMIDE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR APPLICATION METHODS Russian patent published in 2021 - IPC A61K31/165 A61K31/167 A61P21/02 A61P25/00 A61P37/02 C07C235/20 C07C235/22 C07C235/24 C07C235/34 C07C237/20 C07C243/28 C07C255/29 C07C259/06 C07C309/15 C07C311/05 C07D305/08 

FIELD: medicine.

SUBSTANCE: invention relates to a compound of the formula III or its pharmaceutically acceptable salt, which can be used for the treatment of neurodegenerative diseases. In the formula III, R₄ is selected from H and C_1-6 alkyl, and R₃ is: (a) H, OH, NH₂, C_2-6 alkenyl, C_2-6 alkynyl, C_3-6 cycloalkyl or 3-6-element heterocyclic ring containing one heteroatom selected from O; or (b) C_1-6 alkyl optionally substituted with 1, 2 or 3 substituents, each of which is independently selected from OH, halogen, NH₂, -SO₂H, -SO₂(C_1-6 alkyl), CN or phenyl group optionally substituted with 1, 2 or 3 substituents, each of which is independently selected from a group consisting of OH; or (c) -O-C_1-6 alkyl; or (d) phenyl group optionally substituted with 1, 2 or 3 substituents, each of which is independently selected from a group consisting of OH, NO₂ and halogen. Proposed compounds have improved penetration through a blood-brain barrier. The invention also relates to specific compounds and a pharmaceutical composition containing the specified compounds.

EFFECT: obtaining compounds for the treatment of neurodegenerative diseases.

formula III

25 cl, 2 dwg, 1 tbl, 32 ex