FIELD: immunology; biotechnology.
SUBSTANCE: present invention relates to immunology and biotechnology and is a method for increasing the migration of plasmacytoid dendritic cells to mouse thymocytes in vitro. To implement the method, B220+CD11c+ plasmacytoid dendritic cells are obtained from bone marrow cells by culturing them with Flt3-L. Next, plasmacytoid dendritic cells are transfected with a DNA construct encoding the mouse protein CCR9.
EFFECT: present invention makes it possible to increase the efficiency of migration of plasmacytoid dendritic cells to mouse thymocytes.
5 cl, 7 dwg, 1 tbl, 3 ex
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