ATTENUATED ASFV/CV60/2020 STRAIN OF AFRICAN SWINE FEVER VIRUS OF THE ASFARVIRIDAE FAMILY, GENUS ASFIVIRUS FOR THE STUDY OF IMMUNOLOGICAL REACTIONS, MOLECULAR GENETIC ANALYSIS, GENETIC MODIFICATION AND CREATION OF A PROTOTYPE VACCINE AGAINST ASF Russian patent published in 2021 - IPC C12N7/00 

Abstract RU 2760399 C1

FIELD: biotechnology.

SUBSTANCE: invention relates to the field of biotechnology. The invention is a strain of the African swine fever virus "ASFV/CV60/2020". The characterized strain was obtained by deep adaptation by sequential passaging of the virus in a continuous culture of African green monkey kidney cells (CV-1) and deposited in the collection of a microorganism strain of the FSBI "ARRIAH" under registration number 334-dep/20-122. The presented strain has a moderate infectious activity, accumulates in the culture of bone marrow and CV-1 cells. The virulence for pigs of all age groups with intramuscular injection does not exceed 12.5%.

EFFECT: presented virus strain can be used to study immunity factors in pigs when creating a prototype vaccine against African swine fever.

4 cl, 3 dwg, 4 tbl, 5 ex

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RU 2 760 399 C1

Authors

Vlasova Natalya Nikiforovna

Igolkin Aleksej Sergeevich

Mazlum Ali

Pershin Andrej Sergeevich

Zhukov Ivan Yurevich

Shevchenko Ivan Vyacheslavovich

Shotin Andrej Romanovich

Elsukova Aleksandra Andreevna

Aronova Elena Vladimirovna

Dates

2021-11-24Published

2021-04-26Filed