METHOD FOR SYNTHESIS OF SUBSTITUTED UREA COMPOUNDS Russian patent published in 2021 - IPC C07D233/61 

FIELD: organic chemistry.

SUBSTANCE: invention relates to the field of organic chemistry, namely to a method for producing a compound of the formula A or its pharmaceutically acceptable salt, including the interaction of an intermediate compound of the formula IIa' with carbamoyl halogenide of the formula R1R2NC(=O)Hal in a solvent consisting essentially of pyridine, where R6 is NH₂CONH-phenyl or a nitrophenyl, amino-phenyl, or amino-protected amino-phenyl precursor of this group that can be subjected to conversion into NH₂CONH-phenyl group after the formation of urea, and R5 is H, R8 is H, R1 is methyl, and R2 is cyclopentyl, and where Hal is Cl, F, I or Br, and additionally including the processing of a product mixture with water after the formation of urea, where, during oxidation of R5 and R6 derivative, inorganic acid is used, and, when R6 is nitrophenyl, the specified nitrophenyl is converted into amino-phenyl, and obtained amino-phenyl is then converted into NH₂CONH-phenyl group, and, when R6 is amino-phenyl, the specified amino-phenyl is converted into NH₂CONH-phenyl group.

EFFECT: developed method for the production provides for high yield of a compound A having inhibiting activity relatively to FAAH.

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4 cl