PYRIMIDINES AND THEIR OPTIONS, AND THEIR APPLICATION Russian patent published in 2021 - IPC C07D239/48 C07D239/50 C07D401/12 C07D403/12 A61K31/505 A61K31/506 A61P11/00 

FIELD: organic chemistry.

SUBSTANCE: invention relates to organic chemistry, namely to a compound of the formula 1 or its pharmaceutically acceptable salts, where, in the formula 1, W is selected from O and S; X₁ is N; X₂ is CR³; X₃ is CR⁴; X₄ is CR⁵; X₅ is CR⁶; Y is -NR^dR^e, where R^d and R^e are hydrogen; D is absent; R¹ is C_1-12-alkyl; R³, R⁴ and R⁵ each independently is selected from hydrogen; C_1-12-alkyl; C_2-12-alkynyl; halogen; C_1-12-haloalkyl; C_1-12-alkoxy; C_1-12-alkylsulfonyl; ciano; tetrazolyl; -(CH₂)_m-(Z)_n-(CO)-R^f and -(CH₂)_m-(Z)_n-SO₂-(NR^g)_n'-R^f, where m, n and n' each independently is 0 or 1; Z is O or NR^g; R^f and R^g are hydrogen; R⁶ and R⁷ are hydrogen. The invention also relates to a compound 42 and its pharmaceutically acceptable salts, and to a pharmaceutical composition based on compounds of the formula 1 or the compound 42.

EFFECT: pyrimidine derivatives having inhibiting activity relatively to purinergic receptors P2X3 and/or P2X2/3 are obtained.

formula 1,

8 cl, 3 tbl, 49 ex