OESTROGEN RECEPTOR ANTAGONIST Russian patent published in 2024 - IPC C07D209/08 C07D221/02 C07D401/14 C07D409/14 C07D471/04 A61K31/4439 A61K31/437 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (II), an isomer thereof or a pharmaceutically acceptable salt thereof, (II), where X is NH; Y is selected from a group consisting of N and CR₇; Y₁ is CH and Y₂ is N; or Y₁ is N and Y₂ is CH or CF; or Y₁ is CH and Y₂ is CH; L is or ; ring A is selected from the group consisting of phenyl, thienyl and pyridinyl; R₁ is selected from the group consisting of H, halogen and C_1-6 alkyl; R₂ is C_1-3 alkyl, optionally substituted with 1, 2 or 3 R_b; R₃ is selected from the group consisting of H and C_1-3 alkyl; R₁₃ is H or ; R₄ is selected from a group consisting of COOH, , , -NHCH₃ and -N(CH₃)₂; R₅ is H; each of R₆, R₇, R₈ and R₉ independently is H; each of R₁₀, R₁₁ and R₁₂ is independently selected from the group consisting of H, halogen, CN, C_1-3alkyl and -OC_1-3 alkyl; and R_b is selected from the group consisting of H, F, Cl, Br and I, as well as to a pharmaceutical composition based thereon and use in preparing a medicament for treating oestrogen receptor-positive breast cancer.

EFFECT: novel compounds which can be used as oestrogen receptor antagonists for treating oestrogen receptor-positive breast cancer are obtained.

29 cl, 4 tbl, 31 ex