TREATMENT AND FUNCTIONAL CURE OF HIV-INFECTION WITH MONOCLONAL ANTIBODIES TO CD4 MEDIATING COMPETITIVE INHIBITION OF HIV ENTRY Russian patent published in 2021 - IPC C07K16/28 A61K39/12 A61P31/18 

Abstract RU 2762315 C2

FIELD: biochemistry.

SUBSTANCE: invention relates to the field of biochemistry, in particular to an antibody directed against CD4 molecule. A pharmaceutical composition containing the specified antibody, methods for HIV treatment, methods for the inhibition of HIV entry, inhibition of gp120 binding to CD4+ cell, a method for activating a resting CD4+ T-cell, and a method for activating latent HIV reservoir in a resting T-cell using the specified antibody or a pharmaceutical composition are also disclosed.

EFFECT: invention allows for the effective treatment of HIV-infection.

60 cl, 46 dwg, 27 tbl, 16 ex

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RU 2 762 315 C2

Authors

Van Chan I

Dates

2021-12-17Published

2014-11-11Filed