COMPOSITIONS CONTAINING TRIPTANE COMPOUNDS Russian patent published in 2021 - IPC A61K9/08 A61K47/26 A61P25/06 

FIELD: pharmaceutics.

SUBSTANCE: present invention relates to a composition for obtaining a pharmaceutical composition for intranasal administration. The composition contains an aqueous solution including sumatriptan, citric acid in the form of monohydrate and an agent that increases mucosal permeability, which is selected from dodecylmaltoside (1-O-n-dodecyl-β-D-maltopyranoside) and tridecylmaltoside, wherein the mentioned solution has pH from 5.0 to 6.0 and contains 1 molar equivalent of sumatriptan and from about 0.3 to about 0.6 molar equivalent of citric acid in the form of monohydrate. A method for the treatment of a person suffering from migraine or “histamine” headache or cluster headache or having a tendency to migraine or “histamine” headache is also proposed.

EFFECT: new composition for obtaining a pharmaceutical composition containing sumatriptan salt, an agent that increases mucosal permeability, which provides a T_max value less than 30 minutes after the specified administration, and that can be used to treat conditions associated with headache.

11 cl, 4 dwg, 7 tbl, 10 ex