FIELD: biotechnology.
SUBSTANCE: adenoviruses with high immunogenicity and absence of pre-existing immunity in the general human population are described. The absence of pre-existing immunity is due to new hypervariable regions in adenovirus capsid protein hexone. The present invention relates to nucleotide and amino acid sequences of these new strains of adenoviruses, as well as recombinant viruses, virus-like particles and vectors based on these strains. In addition, pharmaceutical compositions and medical applications in the treatment or prevention of a disease and methods for obtaining adenovirus or virus-like particles using new sequences, recombinant viruses, virus-like particles and vectors are provided. New strains of adenoviruses also have an improved capability of reproduction.
EFFECT: invention expands the arsenal of therapeutic agents.
15 cl, 5 dwg, 3 tbl, 6 ex
| Title | Year | Author | Number |
|---|---|---|---|
| MULTIMERIZING POLYPEPTIDES DERIVED FROM DOMAIN WITH ROLL-TYPE PENTONE BASE OF ADENOVIRUS | 2019 |
|
RU2820522C2 |
| AFRICAN SWINE FEVER VACCINE | 2020 |
|
RU2819672C2 |
| DOG ANTIBODIES WITH MODIFIED CH-CH SEQUENCES | 2014 |
|
RU2815059C2 |
| DOG ANTIBODIES WITH MODIFIED CH2-CH3 SEQUENCES | 2014 |
|
RU2801209C2 |
| ADENOVIRUSES AND METHODS FOR ADENOVIRUS APPLICATION | 2019 |
|
RU2782528C1 |
| ANTIGENIC POLYPEPTIDES BASED ON OSPA SEQUENCE | 2019 |
|
RU2816208C2 |
| RECOVERED NUCLEIC ACID WHICH CODES FVIII-BDD-BASED FUSION PROTEIN AND HETEROLOGOUS SIGNAL PEPTIDE, AND USE THEREOF | 2022 |
|
RU2818229C2 |
| ANTIGENIC POLYPEPTIDES BASED ON THE RESPIRATORY SYNCYTIAL VIRUS SEQUENCE | 2019 |
|
RU2807992C2 |
| AAV5-BASED VACCINE FOR INDUCTION OF SPECIFIC IMMUNITY TO SARS-COV-2 VIRUS AND/OR PREVENTION OF CORONAVIRUS INFECTION CAUSED BY SARS-COV-2 | 2020 |
|
RU2760301C1 |
| MUTANT NITRILE HYDRATASE, NUCLEIC ACID WHICH ENCODES SAID MUTANT NITRILE HYDRATASE, EXPRESSION VECTOR AND TRANSFORMANT CONTAINING SAID NUCLEIC ACID, METHOD OF PRODUCING SAID MUTANT NITRILE HYDRATASE AND METHOD OF PRODUCING AMIDE COMPOUND | 2017 |
|
RU2736086C1 |
