FIELD: medicine.
SUBSTANCE: group of inventions relates to vaccinology. Disclosed are antigenic polypeptides based on the sequence of OspA and ferritin protein and use thereof to induce an immune response to Borrelia or to protect a subject from Lyme disease. Also disclosed is a nucleic acid coding an antigenic polypeptide, a ferritin particle, a composition and a method for inducing an immune response to Borrelia or protecting a subject from Lyme disease.
EFFECT: inventions provide self-adjuvant antigenic polypeptides for protection against Borrelia infection with reduced risk of autoimmune response stimulation, allow reducing the total dose required for protection.
19 cl, 25 dwg, 3 tbl, 7 ex
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