FIELD: medicine.
SUBSTANCE: group of inventions relates to vaccinology. Disclosed are antigenic polypeptides based on the sequence of OspA and ferritin protein and use thereof to induce an immune response to Borrelia or to protect a subject from Lyme disease. Also disclosed is a nucleic acid coding an antigenic polypeptide, a ferritin particle, a composition and a method for inducing an immune response to Borrelia or protecting a subject from Lyme disease.
EFFECT: inventions provide self-adjuvant antigenic polypeptides for protection against Borrelia infection with reduced risk of autoimmune response stimulation, allow reducing the total dose required for protection.
19 cl, 25 dwg, 3 tbl, 7 ex
| Title | Year | Author | Number |
|---|---|---|---|
| ANTIGENIC POLYPEPTIDES BASED ON THE RESPIRATORY SYNCYTIAL VIRUS SEQUENCE | 2019 |
|
RU2807992C2 |
| TREATMENT AND PREVENTION OF ALLERGY TO HOUSE DUST MITES | 2019 |
|
RU2815386C2 |
| MULTIMERIZING POLYPEPTIDES DERIVED FROM DOMAIN WITH ROLL-TYPE PENTONE BASE OF ADENOVIRUS | 2019 |
|
RU2820522C2 |
| ISOLATED MODIFIED VPI CAPSID PROTEIN OF ADENO-ASSOCIATED VIRUS OF SEROTYPE 9 (AAV9), CAPSID AND VECTOR BASED THEREON | 2021 |
|
RU2825667C2 |
| ADENOVIRUSES AND METHODS FOR ADENOVIRUS APPLICATION | 2019 |
|
RU2782528C1 |
| POLYPEPTIDE FOR TREATING PATHOLOGICAL BLOOD CLOTS | 2019 |
|
RU2778566C1 |
| DNA ANTIBODY CONSTRUCTIONS FOR USE AGAINST LYME DISEASE | 2017 |
|
RU2813829C2 |
| CONSTRUCTED BOTULINUM NEUROTOXIN | 2017 |
|
RU2789302C2 |
| FMDV RECOMBINANT VACCINES AND USE THEREOF | 2015 |
|
RU2745373C2 |
| ENGINEERED BOTULINUM NEUROTOXIN | 2016 |
|
RU2746736C2 |
