METHOD FOR QUANTITATIVE DETERMINATION OF PHENIBUT IN MICROCAPSULES BY SPECTROPHOTOMETRY Russian patent published in 2021 - IPC G01N21/33 G01N33/15 

FIELD: quality control.

SUBSTANCE: invention relates to the field of quality control of medicines and concerns a method for the quantitative determination of phenibut in microcapsules. The method involves rubbing a phenibut microcapsule to a size of 0.1 mm, preparing a phenibut solution in 0.1 M hydrochloric acid solution, stirring and shaking the sample. The resulting solution is cooled and filtered through a glass filter. The optical density of the test and standard phenibut solutions is measured on a spectrophotometer at the absorption maximum at wavelengths of 257 and 275 nm. The phenibut content in the microcapsule suspension is calculated as the ratio of the product of the mass of the standard sample of phenibut and the optical density of the tested phenibut solution to the product of the mass of microcapsules and the optical density of the solution of the standard sample of phenibut. The optical density of the phenibut solution and the optical density of the phenibut standard sample solution are calculated as the difference in the optical densities of these solutions at wavelengths of 257 nm and 275 nm.

EFFECT: increase in the sensitivity, accuracy and reproducibility of measurements.

1 cl, 2 dwg