FIELD: pharmaceutics.
SUBSTANCE: invention relates to heteroaromatic compounds. A compound of the formula (I) or its pharmaceutically acceptable salt is proposed, where L is selected from C2-4alkenyl, C2-4alkinyl, and R5, which is H or is selected from C1-3alkyl, C1-3heteroalkyl, C3-6cycloalkyl and 4-6-element heterocycloalkyl, which are optionally substituted with 1, 2 or 3 R groups; or R5 and L together form a structural unit , which is ; R1 is selected from H, halogen, OH and NH2 or is selected from C1-3alkyl and C1-3heteroalkyl; R2 is selected from H, F, Cl, Br, I, OH and NH2; R3 is selected from H, halogen, OH, NH2 and CN or is selected from C1-3alkyl and C1-3heteroalkyl; R4 is selected from H, halogen, OH, NH2 and CN or is selected from C1-3alkyl and C1-3heteroalkyl, which are optionally substituted with 1R group; R6 is selected from H, halogen, OH and NH2 or is selected from C1-3alkyl; heteroatom or heterogroup are independently and separately selected from -NH-, N, -O- and -S- in the number of 1, 2 or 3. Specific compounds and use of compounds are also disclosed.
EFFECT: obtaining compounds suitable for use as FGFR inhibitor.
19 cl, 6 tbl, 44 ex
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Authors
Dates
2022-04-29—Published
2018-08-15—Filed