FGFR INHIBITOR AND ITS MEDICAL USE Russian patent published in 2022 - IPC C07D487/04 C07D487/10 A61K31/53 A61K31/5377 A61P35/00 

Abstract RU 2771311 C2

FIELD: pharmaceutics.

SUBSTANCE: invention relates to heteroaromatic compounds. A compound of the formula (I) or its pharmaceutically acceptable salt is proposed, where L is selected from C2-4alkenyl, C2-4alkinyl, and R5, which is H or is selected from C1-3alkyl, C1-3heteroalkyl, C3-6cycloalkyl and 4-6-element heterocycloalkyl, which are optionally substituted with 1, 2 or 3 R groups; or R5 and L together form a structural unit , which is ; R1 is selected from H, halogen, OH and NH2 or is selected from C1-3alkyl and C1-3heteroalkyl; R2 is selected from H, F, Cl, Br, I, OH and NH2; R3 is selected from H, halogen, OH, NH2 and CN or is selected from C1-3alkyl and C1-3heteroalkyl; R4 is selected from H, halogen, OH, NH2 and CN or is selected from C1-3alkyl and C1-3heteroalkyl, which are optionally substituted with 1R group; R6 is selected from H, halogen, OH and NH2 or is selected from C1-3alkyl; heteroatom or heterogroup are independently and separately selected from -NH-, N, -O- and -S- in the number of 1, 2 or 3. Specific compounds and use of compounds are also disclosed.

EFFECT: obtaining compounds suitable for use as FGFR inhibitor.

19 cl, 6 tbl, 44 ex

Similar patents RU2771311C2

Title Year Author Number
DERIVATIVE BASED ON DIHYDROPYRIMIDO-RING AS HBV INHIBITOR 2015
  • Khe Khajin
  • Chzhou Kaj
  • Tsin Khua
  • Li Syaolin
  • Chzhou Yuedun
  • Van Syaofej
  • Chi Syuemej
  • Li Tszyan
  • Chen Shukhuej
RU2693897C2
THIENODIAZEPINE DERIVATIVES AND THEIR USE 2018
  • Shen, Chunli
  • U, Chende
  • Lyu, Yun
  • Gun, Chzhen
  • Li, Tszyan
  • Chen, Shukhuej
RU2795005C2
CDK4/6 INHIBITOR 2017
  • Xu Zhaobing
  • Hu Lihong
  • Ding Charles Z.
  • Chen Shuhui
RU2747311C2
QUINOLINE DERIVATIVES AS SMO INHIBITORS 2015
  • Wu Hao
  • Long Chaofeng
  • Lin Jun
  • Chen Xiaoxin
  • Li Yunhui
  • Liu Zhuowei
  • Wei Changqing
  • Chen Lijuan
  • Chen Shuhui
RU2695815C2
ANALOGUES OF 4H-PYRAZOLO[1,5-A]BENZIMIDAZOLE COMPOUNDS AS PARP INHIBITORS 2015
  • Van Syuekhaj
  • Din Chzhaochzhun
  • Syuj Yun
  • Chen Shukhuej
  • Li Le
  • Li Gan
  • Tu Zhunkhua
  • Van Tsajlin
  • Yue Yan
  • Chzhan Chzhibo
  • Chen Khajlyan
  • Sun Ventsze
  • Khuan Lu
RU2672722C2
COMPOUNDS BASED ON ISOTHIAZOLO[5,4-d]PYRIMIDINE AS IRAK4 INHIBITOR 2019
  • Chzhan, Yan
  • Van, Tszyanfej
  • Tan, Khajchzhun
  • Li, Tsze
  • Li, Tszyan
  • Chen, Shukhuej
RU2801942C2
COMPOUND OF FGFR INHIBITOR IN SOLID FORM AND METHOD OF ITS PREPARATION 2020
  • Fu Zhifei
  • Luo Miaorong
  • Sun Jikui
  • Zhang Yang
  • Li Jian
  • Chen Shuhui
RU2810067C2
S1P1 AGONIST AND ITS APPLICATION 2017
  • Wu, Lingyun
  • Zhang, Peng
  • Li, Jian
  • Chen, Shuhui
RU2754845C2
HYDROXYPURINE COMPOUNDS AND USE THEREOF 2016
  • Wu, Lingyun
  • Chen, Xiaoxin
  • Zhang, Peng
  • Liu, Xing
  • Zhang, Li
  • Liu, Zhuowei
  • Chen, Shuhui
  • Long, Chaofeng
RU2685417C1
MACROCYCLIC ANTIBIOTICS OF WIDE RANGE OF ACTIONS 2016
  • Chen, Yunshen
  • Smit, Peter Endryu
  • Roberts, Taker Karran
  • Khiguchi, Robert I.
  • Paraselli, Prasuna
  • Keler, Majkl F.T.
  • Shvarts, Dzhejkob Bredli
  • Krouford, Dzhejms Dzhon
  • Lyu, Kuong Ts.
  • Khenen, Emili Dzh.
  • Khu, Khuajong
  • Yuj,Chzhioyun
RU2766543C2

RU 2 771 311 C2

Authors

Wang, Yikai

Zhang, Yang

Chen, Zhengxia

Chen, Linlin

Feng, Tao

Huang, Rongxin

Li, Qiu

Li, Deyao

Sun, Jikui

Xu, Yangyang

Li, Jie

Li, Jian

Chen, Shuhui

Dates

2022-04-29Published

2018-08-15Filed