ANTI-SARS-CoV-2-VIRAL PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF Russian patent published in 2022 - IPC A61K31/4965 A61K9/28 A61P31/14 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to an application of a pharmaceutical composition containing micronised favipiravir and excipients, wherein the composition comprises 42.1 wt.% microcrystalline cellulose as a filler, 5.8 wt.% sodium croscarmellose as a disintegrant, 4.9 wt.% povidone as a binder, 0.7 wt.% magnesium stearate as a lubricant, 0.6 wt.% colloidal silicon dioxide, and 2.6 wt.% of a film shell, 43.3 wt.% of micronised favipiravir, with the following size distribution of micronised particles: D(90)=40.6 mcm at Std. Dev. 1.71 mcm, D(50)=10.7 mcm at Std. Dev. 0.459 mcm, and D(10)=2.5 mcm at Std. Dev. 0.0979 mcm, to produce an anti-SARS-CoV-2-viral dosage form in the form of film-coated tablets.

EFFECT: application of the composition of the above composition ensures rapid release of favipiravir from the dosage form (tablets).

1 cl, 4 dwg, 1 tbl, 5 ex