FIELD: medicine; pharmaceuticals.
SUBSTANCE: present invention describes compounds of formulas II and III with radicals disclosed in application materials, or pharmaceutically acceptable salts thereof, as well as methods of using compounds for treating breast cancer by administering to a subject in need thereof a therapeutically effective amount of compounds or pharmaceutically acceptable salts thereof. Breast cancer can be ER-positive breast cancer and/or a subject in need of therapy, can express a mutant ER-α protein.
EFFECT: tetrasubstituted alkene compounds and use thereof are disclosed.
43 cl, 9 dwg, 1 tbl, 109 ex
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