NUCLEIC ACID MOLECULES FOR REDUCING PAPD5 OR PAPD7 MRNA LEVELS FOR TREATING INFECTIOUS HEPATITIS B Russian patent published in 2022 - IPC C12N15/113 A61K31/712 A61K31/7125 A61P31/20 

FIELD: biotechnology.

SUBSTANCE: disclosed is an antisense oligonucleotide for inhibiting expression of PAPD5 and PAPD7. Also disclosed is a conjugated compound containing said antisense oligonucleotide with a conjugate group attached thereto, and pharmaceutically acceptable salts of an antisense oligonucleotide or a conjugated compound. Invention also relates to a pharmaceutical composition having inhibitory activity on PAPD5 and PAPD7, to use of antisense oligonucleotide and compounds containing it in treatment and/or prevention of HBV infection, in particular chronic HBV infection.

EFFECT: ability to inhibit expression of both PAPD5 and PAPD7 by one molecule of antisense oligonucleotide provides advantages in terms of production, ease of delivery to target cells, simplicity of pharmacokinetics/pharmacodynamics (PK/PD) and required concentration to achieve therapeutic benefit.

27 cl, 18 dwg, 43 tbl, 18 ex