FIELD: medicine.
SUBSTANCE: invention relates to a compound used in medicine comprising a modified oligonucleotide and a conjugate group, wherein the modified oligonucleotide consists of 12–30 linked nucleosides and contains a sequence of nitrogenous bases comprising a portion of at least 8 contiguous nitrogen bases complementary to the length of the portion of SEQ ID NO: 1, wherein the nitrogen base sequence of the modified oligonucleotide is at least 90 % complementary to SEQ ID NO: 1, where the conjugate group contains 
where the conjugate group is bound to the modified oligonucleotide at 5'-end or 3'-end of the modified oligonucleotide.
EFFECT: novel compound and composition based on it, effective for the manufacture of a medicament for the treatment of a disease mediated by HBV, have been proposed.
40 cl, 113 ex, 108 tbl
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