FIELD: biotechnology.
SUBSTANCE: disclosed are: an antibody or a functional fragment thereof, which specifically binds to ECL-2 claudin 3, as well as use thereof to produce an agent for detecting claudin 3, as well as for the prevention and treatment of cancer and for the preparation of an agent for diagnosing, imaging, treating cancer and for delivering a drug specific to cancer cells, where the cancer is cancer expressing claudin 3, polynucleotides, expression vectors, cells, a method for producing an antibody or a functional fragment thereof, methods for specific detection of claudin 3, a composition for detecting claudin 3, antibody-drug conjugate and use thereof for preparing an agent for preventing and treating cancer, a composition for specific drug delivery to cancer cells, composition for preventing and treating cancer, comprising an antibody or a functional fragment thereof, a CAR protein, methods for diagnosing and imaging cancer, methods for preventing and treating cancer, method for specific drug delivery into cancer cells.
EFFECT: novel molecule which specifically binds to ECL-2 of claudin 3, enables to use it for effective treatment of cancer.
43 cl, 3 tbl, 7 ex, 31 dwg
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