FIELD: immunology.
SUBSTANCE: antibody to PD-L1 and an antigen-binding fragment are proposed, characterized by amino acid sequences of complementarity-determining regions (hereinafter – CDRs) with SEQ ID NO: 1-3, included in variable regions of a heavy chain, and with SEQ ID NO: 5-7, included in variable regions of a light chain, or with SEQ ID NO: 1, 2, 11, included in variable regions of the heavy chain, and with SEQ ID NO: 13, 6, 7, included in variable regions of the light chain. In addition, nucleic acid encoding the antibody or its antigen-binding fragment; an expression vector; a cell for the production of the antibody or its antigen-binding fragment; a method for the production of the antibody or its antigen-binding fragment; and a composition containing the antibody or its antigen-binding fragment as an active ingredient for prevention or treatment of cancer are proposed.
EFFECT: invention allows for obtainment of a new antibody or its antigen-binding fragment specifically binding to PD-L1, which are effective for prevention or treatment of cancer.
8 cl, 17 dwg, 9 tbl, 15 ex
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