FIELD: biotechnology.
SUBSTANCE: disclosed are immune cells comprising a chimeric antigen receptor (CAR), wherein the CAR comprises an extracellular domain, a transmembrane domain and an intracellular domain comprising a costimulatory endodomain, wherein the costimulatory endodomain comprises an intracellular signalling domain of 4-1BB/CD137 and five additional amino acids. Extracellular domain of CAR contains an antigen-binding domain specifically binding to glypican-3. Also disclosed are nucleic acids, vectors, compositions and methods of treating cancer using engineered immune cells containing CAR.
EFFECT: invention provides improved effectiveness of CAR-T and can be used for treating certain types of cancer.
49 cl, 19 dwg, 1 tbl, 8 ex
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