CRYSTAL STRUCTURE OF GREMLIN-1 AND INHIBITORY ANTIBODY Russian patent published in 2022 - IPC C07K16/18 C12N15/13 C12N15/63 A61K39/395 A61P9/12 

Abstract RU 2769285 C2

FIELD: biotechnology.

SUBSTANCE: disclosed is an antibody which specifically binds to Gremlin-1. Also disclosed is an isolated polynucleotide coding an anti-gremlin-1 antibody, comprising said polynucleotide expression vector and a host cell. Also disclosed is a method of producing anti-gremlin-1 antibody, involving culturing said host cell. Invention also relates to use of said antibody for treating or preventing pulmonary arterial hypertension.

EFFECT: invention provides specific binding with high affinity and inhibiting activity of the antibody with respect to Gremlin-1.

16 cl, 16 dwg, 6 tbl, 8 ex

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RU 2 769 285 C2

Authors

Dedi, Nisha

Tvomej, Breda

Rajt, Majkl Dzhon

Devis, Garet

Makmillan, Devid Dzhejms

Dates

2022-03-30Published

2017-12-19Filed