CRYSTAL STRUCTURE OF GREMLIN-1 AND INHIBITORY ANTIBODY Russian patent published in 2022 - IPC C07K16/18 C12N15/13 C12N15/63 A61K39/395 A61P9/12 

Abstract RU 2769285 C2

FIELD: biotechnology.

SUBSTANCE: disclosed is an antibody which specifically binds to Gremlin-1. Also disclosed is an isolated polynucleotide coding an anti-gremlin-1 antibody, comprising said polynucleotide expression vector and a host cell. Also disclosed is a method of producing anti-gremlin-1 antibody, involving culturing said host cell. Invention also relates to use of said antibody for treating or preventing pulmonary arterial hypertension.

EFFECT: invention provides specific binding with high affinity and inhibiting activity of the antibody with respect to Gremlin-1.

16 cl, 16 dwg, 6 tbl, 8 ex

Similar patents RU2769285C2

Title Year Author Number
GREMLIN-1 INHIBITOR FOR THE TREATMENT OF BONE FRACTURE OR BONE DEFECT 2019
  • Davies, Gareth Charles Glyndwr
  • Roberts, Scott John
RU2790992C2
PREDICTION OF RISK OF DEVELOPMENT OF UNDESIRED REACTION RELATED TO ADMINISTRATION OF ANTIBODY TO ALK2 AND CAPABILITY OF RESPONDING TO TREATMENT WITH ANTIBODY TO ALK2 2019
  • Katagiri Takenobu
  • Tsukamoto Sho
  • Kumagai Keigo
  • Tsuji Shinnosuke
RU2783762C2
CONNECTIVE TISSUE GROWTH FACTOR ANTIBODY AND USE THEREOF 2020
  • Fu, Yayuan
  • Ma, Syaoli
  • Ge, Khu
  • Tao, Vejkan
RU2819228C2
ANTIBODIES TO MYOSTATIN, POLYPEPTIDES CONTAINING FC-REGION VARIANTS, AND THEIR APPLICATION METHODS 2016
  • Kuramoti Tajti
  • Igava Tomoyuki
  • Katada Khitosi
  • Khori Yudzi
RU2789884C2
FUSED PROTEIN CONSTRUCTS FOR COMPLEMENT-RELATED DISEASE 2019
  • Kertis, Majkl Stiven
  • Storek, Majkl
  • Vajolett, Sheliya Mari
  • Kalled, Syuzan L.
  • Fakhnou, Kelli S.
  • Khuan, Chen Zhan
  • Stark, Ellen Garber
  • Tejlor, Frederik Robbins
  • Karavella, Dzhastin Endryu
  • Kholers, Vernon Majkl
RU2824402C2
POLYPEPTIDE COMPRISING ANTIGEN-BINDING DOMAIN AND TRANSPORT SEGMENT 2017
  • Igawa Tomoyuki
  • Ishikawa Hiroyuki
  • Hironiwa Naoka
RU2827545C2
ANTI-CD137 ANTIGEN-BINDING MOLECULES AND USE THEREOF 2019
  • Igawa Tomoyuki
  • Sakurai Mika
  • Shimizu Shun
  • Hori Yuji
  • Hironiwa Naoka
  • Savory Nasa
  • Narita Yoshinori
  • Kamikawa Takayuki
  • Miyazaki Taro
  • Kadono Shojiro
  • Hasegawa Masami
  • Tatsumi Kanako
  • Hayasaka Akira
  • Kawai Takeaki
  • Mimoto Futa
  • Kawauchi Hiroki
  • Kamimura Masaki
RU2829536C2
BISPECIFIC ANTIBODY AGAINST RABIES VIRUS AND ITS APPLICATION 2019
  • Liu Zhigang
  • Hao Xiaobo
  • Liu Yulan
  • Guo Jingjing
RU2764740C1
ANTIBODIES TO MYOSTATIN AND THEIR APPLICATION METHODS 2017
  • Rujke Esinao
  • Kuramoti Tajti
  • Muramatsu Khiroyasu
  • Ueyama Atsunori
RU2778945C2
IMMUNOCYTOKINES AND THEIR USE 2021
  • Wu Ellen
  • Wu Xiaoyun
  • Wakefield John
RU2818371C1

RU 2 769 285 C2

Authors

Dedi, Nisha

Tvomej, Breda

Rajt, Majkl Dzhon

Devis, Garet

Makmillan, Devid Dzhejms

Dates

2022-03-30Published

2017-12-19Filed