FIELD: biotechnology.
SUBSTANCE: disclosed is an antibody which specifically binds to Gremlin-1. Also disclosed is an isolated polynucleotide coding an anti-gremlin-1 antibody, comprising said polynucleotide expression vector and a host cell. Also disclosed is a method of producing anti-gremlin-1 antibody, involving culturing said host cell. Invention also relates to use of said antibody for treating or preventing pulmonary arterial hypertension.
EFFECT: invention provides specific binding with high affinity and inhibiting activity of the antibody with respect to Gremlin-1.
16 cl, 16 dwg, 6 tbl, 8 ex
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