FIELD: biotechnology.
SUBSTANCE: invention relates to a fused protein construct, which binds a complement fragment C3 C3d, containing an antibody or its antigen-binding fragment, which specifically binds to C3d, and a complement modulator polypeptide, as well as to a composition containing same. Also disclosed is an antibody or its antigen-binding fragment, which specifically binds to a complement fragment C3 C3d.
EFFECT: invention is effective for treating a disease mediated by a complement fragment C3 C3d, as well as for producing a drug for treating a disease mediated by a complement fragment C3 C3d.
43 cl, 35 dwg, 36 tbl, 20 ex
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