FUSED PROTEIN CONSTRUCTS FOR COMPLEMENT-RELATED DISEASE Russian patent published in 2024 - IPC C07K16/18 C07K14/47 C07K14/725 A61K38/17 A61K39/395 A61P29/00 A61P35/00 

Abstract RU 2824402 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to a fused protein construct, which binds a complement fragment C3 C3d, containing an antibody or its antigen-binding fragment, which specifically binds to C3d, and a complement modulator polypeptide, as well as to a composition containing same. Also disclosed is an antibody or its antigen-binding fragment, which specifically binds to a complement fragment C3 C3d.

EFFECT: invention is effective for treating a disease mediated by a complement fragment C3 C3d, as well as for producing a drug for treating a disease mediated by a complement fragment C3 C3d.

43 cl, 35 dwg, 36 tbl, 20 ex

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RU 2 824 402 C2

Authors

Kertis, Majkl Stiven

Storek, Majkl

Vajolett, Sheliya Mari

Kalled, Syuzan L.

Fakhnou, Kelli S.

Khuan, Chen Zhan

Stark, Ellen Garber

Tejlor, Frederik Robbins

Karavella, Dzhastin Endryu

Kholers, Vernon Majkl

Dates

2024-08-07Published

2019-12-11Filed