FIELD: biotechnology.
SUBSTANCE: disclosed are versions of an antibody which specifically binds to GARP. Also disclosed is a polynucleotide coding said antibody, comprising said polynucleotide expression vector and a host cell, a method of producing said antibody. Invention also relates to a pharmaceutical composition for use in anticancer therapy and a method of treating a tumor using said antibody.
EFFECT: invention provides producing an anti-GARP antibody which exhibits inhibitory activity on Treg function, exhibits ADCC activity and can be used as a therapeutic anticancer agent.
37 cl, 45 dwg, 2 tbl, 11 ex
| Title | Year | Author | Number |
|---|---|---|---|
| MULTI-SPECIFIC ANTIGEN-BINDING MOLECULE HAVING SUBSTITUTE FUNCTIONAL ACTIVITY OF BLOOD COAGULATING FACTOR VIII CO-FACTOR, AND PHARMACEUTICAL COMPOSITION CONTAINING SPECIFIED MOLECULE AS ACTIVE INGREDIENT | 2018 |
|
RU2812909C2 |
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|
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|
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|
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| ANTIBODY AGAINST CD147 | 2018 |
|
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| HUMAN TLR7 ANTIBODY | 2019 |
|
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| ANTIBODY TO HUMAN CD73 | 2017 |
|
RU2754058C2 |
