FIELD: biotechnology.
SUBSTANCE: antibody specifically binding to GPR20 and an antibody-drug conjugate for the treatment of tumor, containing the specified antibody, are proposed. Polynucleotide encoding the specified antibody, an expression vector, a host cell, and a method for the production of an antibody are also proposed. In addition, the invention relates to pharmaceutical compositions and methods for the treatment of tumor using the specified antibodies and conjugates.
EFFECT: invention provides for high activity of antibody internalization into GPR20-expressing cells.
67 cl, 41 dwg, 1 tbl, 9 ex
| Title | Year | Author | Number |
|---|---|---|---|
| ANTIBODY AGAINST SIRPα | 2019 |
|
RU2791002C2 |
| ANTIBODY AGAINST CD147 | 2018 |
|
RU2785293C2 |
| ANTIBODIES AGAINST OX40 AND THEIR USE | 2017 |
|
RU2783314C2 |
| ANTI-GARP ANTIBODY | 2016 |
|
RU2769379C2 |
| ANTIBODY AGAINST MUC1 | 2019 |
|
RU2792347C2 |
| ANTIBODIES AGAINST CD40 AND THEIR USE | 2018 |
|
RU2796413C2 |
| ANTIBODIES AGAINST CTLA4 AND THEIR USE | 2017 |
|
RU2779312C2 |
| HUMAN TLR7 ANTIBODY | 2019 |
|
RU2808123C2 |
| ANTIBODY AGAINST CLAUDIN 18A2 AND ITS USE | 2020 |
|
RU2811431C2 |
| HUMANIZED MONOCLONAL ANTIBODY AGAINST Aβ AND ITS USE | 2020 |
|
RU2783528C1 |
