IRREVERSIBLE ELECTROPORATION (IEP) BASED ON IMPEDANCE Russian patent published in 2022 - IPC A61B18/14 A61B5/53 

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine, namely to the method for irreversible electroporation (IEP) and the system for its implementation. In this case, catheter electrodes are selected to supply IEP pulses to the organ tissue between the selected electrodes. A IEP protocol is established containing an impedance threshold. The impedance between the selected electrodes is measured. The measured impedance is compared with a given threshold. If the measured impedance is below the threshold, the IEP protocol is changed so that the new impedance threshold is below the measured impedance. Changing the IEP protocol involves changing the pulse width, pulse repetition rate and/or the number of IEP pulses that meet the specified safety criterion for the measured impedance. IEP pulses are supplied in accordance with the modified protocol. Safe ablation is provided with protection against excessive Joule heating of the tissue by maintaining the value of the supplied energy similarly to the planned value using modified parameters of the IEP pulses so that the heat generated can spread to a greater extent and the maximum temperature caused by heating decreases in order to perform ablation at a given impedance with the same clinical and thermal effect.

EFFECT: expansion of the range of electroporation methods.

10 cl, 2 dwg, 2 tbl