METHOD FOR PRESCRIBING INDIVIDUAL ANTITHROMBOTIC THERAPY IN ACUTE AND EARLY PERIODS OF SPINOCRONOUS INJURY OF THE CERVICAL SPINE Russian patent published in 2022 - IPC A61B8/00 A61B5/1455 A61K31/727 A61K31/506 A61P7/02 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to anesthesiology and resuscitation, traumatology and orthopedics, and can be used in the prevention and treatment of venous thromboembolic complications (VTEC) in patients with spinal cord injury (SCI) of the cervical region in the acute and early periods. To achieve this, a prophylactic dose of anticoagulants is administered, the state of the hemostasis system is monitored by low-frequency piezothromboelastography (LPTEG) on the 1st, 3rd, 7th, 10th, 15th, 20th days, and an ultrasound examination (ultrasound) of the veins is performed on the 1st day. If normocoagulation, normoaggregation are detected and there is no data on venous thrombosis and thromboembolic complications (VTEC) according to the results of ultrasound, the introduction of a prophylactic dose of anticoagulants is continued. When VTEC is detected according to ultrasound of the veins, a therapeutic dose of anticoagulants is administered, regardless of the indicators of the state of the hemostasis system, until stable hypocoagulation is achieved. If normocoagulation and hyperaggregation are detected, a prophylactic dose of anticoagulants is administered in combination with antiplatelet drugs. If normocoagulation and hypoaggregation are detected, a prophylactic dose of anticoagulants is administered. When hypercoagulation and normoaggregation are detected, a therapeutic dose of anticoagulants is administered. If hypocoagulation and normoaggregation are detected, a prophylactic dose of anticoagulants is administered. When hypercoagulation and hyperaggregation are detected, a therapeutic dose of anticoagulants is administered in combination with antiplatelet drugs. If hypocoagulation and hypoaggregation are detected, a prophylactic dose of anticoagulants is administered. LPTEG and correction of antithrombotic therapy according to the monitoring data are carried out until the reference values ​​of the indicators of the state of the hemostasis system are reached, and then again on the 1st, 3rd, 7th, 10th, 15th, 20th days. Ultrasound of the veins is carried out further every 10 days.

EFFECT: method provides at early stages, before clinical manifestations of thrombosis, to assess the state of hemostasis at a specific point in time and to carry out the necessary correction of therapy, taking into account the individual characteristics of the vascular-platelet component of hemostasis of a particular patient, preventing thrombosis and minimizing the risk of bleeding.

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