FIELD: molecular biology.
SUBSTANCE: options of a DNA aptamer intended for specific binding to human PrimPol and inhibiting its DNA polymerase and primase activities are proposed.
EFFECT: group of inventions provides for inhibiting DNA-synthesizing PrimPol activity, which is achieved by the interaction of DNA aptamers with PrimPol molecule.
2 cl, 1 dwg, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| DNA-APTAMERS TO HUMAN DNA ETA POLYMERASE | 2020 |
|
RU2737285C1 |
| DNA-APTAMER WITH HIGH AFFINITY TO INTERLEUKIN-6 PROTEIN | 2023 |
|
RU2814541C2 |
| DNA-APTAMERS INTERACTING WITH PROTHROMBIN | 2018 |
|
RU2703799C1 |
| METHOD FOR OBTAINING THERAPEUTIC AGENT FOR CURING OF TICK-BORNE ENCEPHALITIS | 2012 |
|
RU2501862C1 |
| METHOD FOR CREATION AND SELECTION OF THE LIBRARY OF MODIFIED APTAMERS | 2016 |
|
RU2652952C1 |
| METHOD FOR DETERMINING SUBSTRATE EFFICIENCY OF DEOXYURIDINE TRIPHOSPHATES DERIVATIVES FOR DNA POLYMERASES BY PRIMER COMPLETION REACTION | 2019 |
|
RU2731739C1 |
| COMPLEMENT-BINDING APTAMERS AND C5 AGENTS APPLICABLE FOR TREATING OCULAR DISORDERS | 2007 |
|
RU2477137C2 |
| DNA-APTAMER BINDING AN EXTRACELLULAR DOMAIN OF EGFR | 2018 |
|
RU2700097C1 |
| IN VITRO ANALYSIS OF DNA-POLYMERASE ACTIVITY OF HEPATITIS B VIRUS (HBV) AND ITS APPLICATION FOR SCREENING FOR INHIBITORS OF HBV DNA-POLYMERASE | 1999 |
|
RU2202620C2 |
| APTAMERS ON BASIS OF DNA FOR HUMAN CATHEPSINE G | 2004 |
|
RU2360000C2 |
