FIELD: biotechnology.
SUBSTANCE: invention relates to DNA aptamers having high affinity to interleukin-6 protein.
EFFECT: proposed invention is effective for binding interleukin-6 and can be used for its detection or for slowing down interaction of interleukin-6 with cell receptors.
1 cl, 4 dwg, 1 tbl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| RECOMBINANT SINGLE-DOMAIN ANTIBODIES SPECIFICALLY BINDING HUMAN INTERLEUKIN-6, METHOD FOR THEIR PREPARING AND USING FOR DETECTION OF THIS PROTEIN | 2015 |
|
RU2603269C1 |
| NUCLEOTIDE SEQUENCE CODING FUSION PROTEIN CONSISTING OF SOLUBLE EXTRACELLULAR FRAGMENT OF HUMAN IL-6R AND CONSTANT PART OF HEAVY CHAIN OF HUMAN IGG4 | 2023 |
|
RU2818329C1 |
| THERAPEUTIC ANTIBODY SPECIFIC TO INTERLEUKIN-11, INHIBITING SIGNALING THROUGH ITS RECEPTOR, AND METHOD FOR ITS USE FOR THE TREATMENT OF PATIENTS | 2019 |
|
RU2753973C2 |
| DNA-APTAMER BINDING AN EXTRACELLULAR DOMAIN OF EGFR | 2018 |
|
RU2700097C1 |
| RNA-APTAMER HAVING ABILITY TO RECOGNISE AUTOANTIBODIES SPECIFIC TO DISSEMINATED SCLEROSIS | 2014 |
|
RU2549704C1 |
| IMPROVED AMINO ACID SEQUENCES AGAINST IL-6R AND POLYPEPTIDES WHICH CONTAIN THEREOF FOR TREATMENT OF IL-6R ASSOCIATED DISEASES AND DISORDERS | 2010 |
|
RU2539798C2 |
| DNA APTAMER THAT SPECIFICALLY BINDS TO HUMAN DICKKOPF-1 PROTEIN | 2023 |
|
RU2814580C1 |
| HUMANIZED IL-6 AND IL-6 RECEPTOR | 2012 |
|
RU2751240C2 |
| HUMANISED IL-6 ANTIBODIES | 2009 |
|
RU2532826C2 |
| ANTIGENS ASSOCIATED WITH INFLAMMATORY BOWEL DISEASE | 2012 |
|
RU2612878C2 |
