PYRAZOLE COMPOUNDS, THEIR PHARMACEUTICAL COMPOSITIONS AND THEIR APPLICATION Russian patent published in 2022 - IPC C07D401/14 A61K31/4439 A61K31/41 A61P35/00 A61P37/02 A61P29/00 

FIELD: pharmaceutics.

SUBSTANCE: invention relates to a compound of formula (IA) or its pharmaceutically acceptable salt, a method for its preparation and its use in the manufacture of a drug for inhibiting kinases of the IRAK family. The compounds may be useful for the treatment of diseases caused by IRAK kinases, such as autoimmune diseases, inflammatory diseases and some cancers. In the general formula (IA) R⁴ is selected from COR^d, CONR^bR^c, CO₂R^d or SO₂R^d; R⁵ is selected from H, C_1-6 alkyl, C_3-6-cycloalkyl; where alkyl or cycloalkyl is unsubstituted or replaced by 1-3 R^5a; R^5a is selected from H, D, halogen, cyano, C_1-6 alkyl, OR_a, NR^bR^c; where C_1-6 alkyl is unsubstituted or replaced by 1-3 R^5b; R^5b is selected from H, D, halogen, cyano, OR^a or NR^bR^c; R⁸ is selected from H or D; R^a is selected from H, D or C_1-6 alkyl; R^b, R^c each is selected from H, D or C_1-6 alkyl; R^d is selected from H, D, C_1-6 alkyl, C_2-6 alkenyl, where alkyl or alkenyl is unsubstituted or replaced by 1-4 R⁶; R⁶ is selected from H, D, halogen, cyano, OR^a, C_1-6 alkyl and z is equal to 1 or 2.

EFFECT: provision of IRAK4 inhibitors of the formula (IA), the method for their preparation and their use in the manufacture of a drug for inhibiting kinases of the IRAK family.

4 cl, 2 tbl, 43 ex